RESUMO
The learning of cytyogenetic special of cariotip in children with the bronchial asthma maked by course of the investigation of prometahyases chromosomes of limphocytes of the periferic bloods. The quantity of association of acrocentric chromosome was analised. The 82 children in age 6-18 years old with the bronchial asthma and with the different control were learned by results of asthma--test control. In children with the noncontrol bronchial asthma the big frequency of of association of acrocentric chromosome 13-15 (D-D), 21-22 (G-G) n 13-15--21-22 (D-G) were received. In patients with the bronchial asthma the lover mitotic activity by healthy were marked (P(N) < 0.05). With the degree of activity it was decreased.
Assuntos
Asma/genética , Aberrações Cromossômicas , Cromossomos Humanos 13-15/genética , Cromossomos Humanos 21-22 e Y/genética , Linfócitos , Prometáfase/genética , Adolescente , Asma/patologia , Asma/prevenção & controle , Criança , Marcadores Genéticos , Humanos , Cariótipo , Cariotipagem , Linfócitos/patologiaRESUMO
The phenotype characteristics of bronchial asthma in 94 children from the Ivano-Frankivsk region with different variations of allelic gene polymorphism of the 2-nd phase of xenobiotics detoxification: GSTM1 and GSTT1 have been studied. The association between the polymorphism of such genes, liability to developing and severity of asthma in children has been described. It has been determined that the implementation of asthma as ecodeterminated pathology is affected by individual variations of metabolic activity of genes of xenobiotics detoxification. It's proved that in patients with uncontrolled asthma genotypes del/del on both genes glutathione-S-transferase (GSTM1 and GSTT1) were met much more common.
Assuntos
Asma/enzimologia , Glutationa Transferase/genética , Polimorfismo Genético , Xenobióticos/farmacocinética , Adolescente , Asma/epidemiologia , Asma/genética , Estudos de Casos e Controles , Criança , Frequência do Gene , Humanos , Desintoxicação Metabólica Fase II , Reação em Cadeia da Polimerase , Índice de Gravidade de Doença , UcrâniaRESUMO
The aim of our work was the study of macro-and microelemensts characteristics of the state of the blood serum of children with asthma, depending on the severity. A total of 107 children aged 10 to 18 years with asthma in the acute stage. The results of the proposed asthma control test (GINA, 2011) to the level of asthma control the children were distributed as follows: 34 (31.8%)--with controlled, 47 (43.9%)--partly controlled and 26--with uncontrolled bronchial asthma. Investigation of serum trace elements were determined by atomic absobtsionnoy spectrophotometry. Found that with varying degrees of control of asthma changes were reduction of magnesium, zinc, when excessive amounts of copper and calcium. We show some dizelements in patients with nontrol bronhial asthma. The most pronounced manifestation dyzelements documented in patients with uncontrolled asthma. It is with same with uncontrolled asthma, there are marked hypoxic change, energy shortage, bronchial hyperreactivity, as a result of increasing stress level of response to an antigen, reduce antioxidant enzyme systems, immune system dysfunction. This changes in the macro-and microelement composition of the blood significantly reduce the reserves of the immune system, chronic inflammatory processes in the bronches, which exacerbates the severity of the disease, which in practice requires a differential diagnosis, comprehensive treatment based on identified dyzelements states.
